Endocrine Abstracts

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

Objective: To assess the impact of genetic polymorphisms associated with increased cardiovascular risk on the lipid profile in healthy postmenopausal women.Methods: The study population consisted of 84 women between 49–69 years who had been menopausal for at least one year. The genetic polymorphisms examined were the following: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenotetrahydrofolate reductase ala222val, Apolipoprotein B arg350...

Objective: To assess the interrelation of the MTHFR ala222val polymorphism, correlated with increased rates of cardiovascular disease, with indices of androgenicity in healthy postmenopausal women.Methods: The population of this cross-sectional study consisted of 84 healthy women who had been menopausal for at least one year. The examined polymorphism was Methylenetetrahydrofolate reductase ala222val, while the hormonal assays included Testosterone, Sex ...

IntroductionThe routine assessment of postmenopausal women involves screening for cardiometabolic risk factors and bone health. Evaluation of the liver function is not commonly performed, even though this could be easily performed with the use of indirect markers, such as the Fibrosis 4 score. Recent evidence supports an association between liver cirrhosis and bone turnover, affecting both the trabecular and the cortical bone. Therefore, we aimed to expl...

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence of the impact of BS on antenatal glycaemic control. We present three cases of pregnancy post-BS, who experienced various degrees of hypoglycaemia during gestation.Case presentations: Three women aged 25-, 26-, and 36-years-old, who were previously euglycaemic, presented to the joint antenatal clinic wi...

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence on the impact of BS on antenatal glycaemic control. We present four cases of pregnancy post-BS, reviewed in the joint antenatal clinic, who experienced various degrees of hypoglycaemia during pregnancy.Case presentations: Four pregnant women (cases A–D, aged 25–36-years-old, 3–8years pos...

Summary: 59-year-old female diagnosed at the age of 41 in 2004 with pseudohypoparathyroidism (PHP) initially presenting with raised PTH 152 pmol/l (1.6-6.9), Phosphate 1.91 mmol/l (0.87-1.45), adjusted calcium 1.90 mmol/l (2.20-2.60), raised ALP 600 units/l (0-129) and low vitamin D 29 nmol/l. Since diagnosis started on alfacalcidol 1 mg daily and Calcichew-D3. Investigations by hepatology team in the view of persistently raised ALP showed normal liver ultrasound, Fibroscan an...

Introduction: Pituitary metastasis (PM) is a rare condition and associated with a reduced life-span. The most common primary sites are breast and lung, followed by thyroid and renal cell carcinoma. Patients with PM are mostly asymptomatic and incidentally discovered during neuroimaging. Characteristic symptoms are reported in <20% and most commonly include visual involvement, diabetes insipidus, and panhypopituitarism. We here describe a case with malignant melanoma (MM) w...

Objective: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Methods: This cross-sectional study included 420 postmenopausal w...

Objective: Differences in body weight and clinical features of typical vs atypical anorexia nervosa (A.N) might be explained by the genetic background. We aimed to evaluate the association between the subtypes of A.N. and the genetic polymorphisms of the thrombotic panel or the methyltetrahydrofolate reductase (MTHFR) gene.Methods: A total of 40 adolescent girls with A.N., aged 13–19 years, were evaluated. We recorded anthropometric parameters, amen...